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Study on the Acute Brain Aging Rat Model by Radiation
Author(s): 
Pages: 208-210,214
Year: Issue:  4
Journal: LABORATORY ANIMAL AND COMPARATIVE MEDICINE

Keyword:  脑老化模型电离辐射大鼠;
Abstract: 目的根据衰老的自由基理论,建立一种简便易行的脑老化模型.方法以60 Co照射大鼠建立急性脑老化模型、D-半乳糖注射大鼠建立亚急性脑老化模型,5月龄大鼠作为青年对照组;通过Y型迷宫测定大鼠的学习与记忆能力;外周血SOD和MDA检测大鼠的抗氧化能力及脂质过氧化情况;通过光镜观察脑组织神经细胞的丢失、坏死及退行性变.结果Y型迷宫测定表明,两个模型组大鼠的学习和记忆能力比对照组明显下降;与对照组相比,外周血中SOD明显降低,而MDA则明显升高;光镜下,在模型组不同脑区均能观察到神经元的丢失和坏死,以海马和皮质最明显.结论成功建立了一种简便易行的急性脑老化模型;为脑老化机制的研究提供了新的实验手段.
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