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Establishing Mice Model of Multidurg Resistance of Tumor Induced by Combined-chemotherapy
Author(s): 
Pages: 215-217
Year: Issue:  4
Journal: LABORATORY ANIMAL AND COMPARATIVE MEDICINE

Keyword:  肿瘤多药耐药小鼠P170LRPTOPOⅡ;
Abstract: 目的建立小鼠在体肿瘤多药耐药模型.方法模拟临床以亚于治疗剂量的联合化疗PFC方案,诱导S180腹水型小鼠4周,流式细胞仪荧光检测P170、LRP、TOPOⅡ,建立能客观反应临床肿瘤多药耐药产生机制并适合中药干预肿瘤多药耐药研究的在体细胞模型.结果化疗诱导后昆明小鼠S180腹水肿瘤细胞P170、LRP的表达率和ROPOⅡ活性明显提高,经传代后其表达稳定.结论联合化疗诱导建立小鼠在体肿瘤多药耐药模型是可行的.
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