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Establishment of Allergic Asthma Model in Guinea Pigs
Author(s): 
Pages: 204-206
Year: Issue:  4
Journal: SHANGHAI LABORATORY ANIMAL SCIENCE

Keyword:  豚鼠过敏性哮喘模型;
Abstract: 为制备过敏性哮喘模型,腹腔注射抗原(卵蛋白,OA)致敏豚鼠,2周后使豚鼠吸入雾化卵蛋白激发哮喘发作,以正常豚鼠为空白对照组,比较血、支气管肺泡灌洗液(BALF)中的嗜酸细胞及BALF细胞总数及气道反应性,并进行病理学检查以确定动物造模是否能模拟哮喘的病理状态.结果表明卵蛋白激发后,豚鼠的血、支气管肺泡灌洗液(BALF)中的嗜酸细胞总数较对照组增高,吸入组胺后气道内压较对照组明显增高,病理学结果显示为嗜酸性炎性浸润.
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