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ren duo fa xing gu sui liu he liu scid xiao shu mo xing de jian li ji qi sheng chang te xing
Author(s): 
Pages: 230-233
Year: Issue:  4
Journal: SHANGHAI LABORATORY ANIMAL SCIENCE

Keyword:  多发性骨髓瘤SCID小鼠细胞毒性T淋巴细胞;
Abstract: 为研究人多发性骨髓瘤(Multiple Myeloma,MM)在SCID小鼠免疫重建前后体内生长的特性和免疫细胞对肿瘤的作用,建立人多发性骨髓瘤(MM)荷瘤SCID小鼠模型.体外培养IL-6依赖的人MM细胞株XG7,接种于SCID小鼠和用人淋巴细胞重建的SCID小鼠皮下;监测成瘤状态,通过免疫组化观察细胞毒性T淋巴细胞(Cytotoxic T lymphocytes,CTLs)杀伤.结果表明:成瘤后的肿瘤细胞CD28、CD138等分子的表达与接种前没有明显变化;免疫重建后的SCID小鼠成瘤潜伏期延长,瘤体积小;免疫重建后的SCID小鼠肿瘤组织中,有人CD3+T细胞的浸润.结果提示:SCID小鼠是建立肿瘤模型和肿瘤免疫研究的良好动物;免疫重建后的SCID小鼠体内肿瘤生长受抑制;人MM细胞在小鼠体内的生长状态与淋巴细胞免疫有关.
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