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Research advances in the action of fibroblast growth factors in inflammatory diseases and its clinical application
Author(s): 
Pages: 831-836
Year: Issue:  12
Journal: Qilu Pharmaceutical Affairs

Keyword:  成纤维细胞生长因子炎症反应炎症性疾病;
Abstract: 成纤维细胞生长因子(fibroblast growth factors,FGFs)是一类生长因子,以旁分泌或内分泌的方式,参与多种生物学过程,包括细胞增殖与分化、胚胎发育、血管生成、伤口愈合、组织修复及调控糖脂代谢等.随着对其家族研究的深入,近年来发现旁分泌生长因子成纤维细胞生长因子2(FGF2)、成纤维细胞生长因子10(FGF10)和内分泌生长因子成纤维细胞生长因子21(FGF21)、成纤维细胞生长因子23(FGF23)对于炎症性疾病中的炎症反应具有重要的调控作用,这些发现为炎症性疾病的诊疗提供了新的思路.本文总结成纤维细胞生长因子在炎症性疾病方面的最新研究进展,为成纤维细胞生长因子药物临床开发及应用提供参考.
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