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Crosstalk between tryptophan metabolism and kidney disease,mechanisms and therapeutic implications
Author(s): 
Pages: 598-604
Year: Issue:  9
Journal: Qilu Pharmaceutical Affairs

Keyword:  色氨酸代谢急性肾损伤慢性肾病肾癌;
Abstract: 急性肾损伤(AKI)、慢性肾病(CKD)与肾癌(RCC)是临床上典型的肾脏疾病,其发病机制复杂且易诱发多种并发症而造成全身性损伤.近年来的研究揭示,色氨酸代谢与抑郁症、自身免疫性疾病、神经退行性疾病与癌症等疾病的发生发展密切相关,其在肾脏疾病的发生发展过程中亦发挥着重要作用.本文综述了色氨酸代谢与急性肾损伤、慢性肾病及肾癌等肾脏疾病的互作研究进展,总结分析了靶向色氨酸代谢的肾脏疾病干预策略,以期为肾脏疾病诊断和防治提供借鉴.
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