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Research progress of removing cholesterol crystals for anti-atherosclerosis
Author(s): 
Pages: 52-55,67
Year: Issue:  1
Journal: Qilu Pharmaceutical Affairs

Keyword:  动脉粥样硬化胆固醇结晶心脑血管疾病炎症斑块;
Abstract: 动脉粥样硬化是导致心脑血管疾病的主要诱因.主动脉血管内皮下斑块的形成是动脉粥样硬化的病理特征,而在斑块中胆固醇结晶的出现不仅会加剧斑块炎症反应,还会造成斑块去稳定和破裂,最终导致心脑血管事件.因此,清除斑块胆固醇结晶将有利于动脉粥样硬化的归转.本文综述了斑块中胆固醇结晶的形成过程和特点、胆固醇结晶促进动脉粥样硬化的作用机制以及清除斑块胆固醇结晶的策略,为开发以斑块胆固醇结晶为靶点的抗动脉粥样硬化药物提供理论依据和参考.
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