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Status and progress of pulmonary drug delivery systems in the treatment of lung infections
Author(s): 
Pages: 659-665
Year: Issue:  11
Journal: Qilu Pharmaceutical Affairs

Keyword:  抗菌药物细菌耐药铜绿假单胞菌吸入制剂药物递送系统;
Abstract: 近年来,社区获得性肺炎成为最为常见的肺部感染,发病群体极为广泛,造成严重的健康威胁.本文对抗菌药物细菌耐药性、药物递送系统(DDS)在肺部感染治疗方面的优势和研究难点等研究进行归纳和总结,简要介绍了抗菌药物在肺部治疗的现状,针对肺部感染的药物递送,特别是针对铜绿假单胞菌(PA)感染,讨论了目前肺部递送抗菌药物载体的研究进展及药物递送系统与肺部生物屏障的相互作用,以期为解决抗菌药物治疗方面面临的重大问题和克服肺部生物学屏障、提高药物在感染病灶的生物利用度提供一种新的思路.
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