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Preparation of poloxamer 407 modified gefitinib liposome and study of its antitumor activity
Author(s): 
Pages: 510-515
Year: Issue:  9
Journal: Qilu Pharmaceutical Affairs

Keyword:  吉非替尼脂质体泊洛沙姆407抗肿瘤;
Abstract: 目的 制备并评价泊洛沙姆407修饰的吉非替尼脂质体(GFB-PML),考察体内外抗肿瘤活性.方法 薄膜分散法制备吉非替尼脂质体,透射电镜观察形态;高效液相色谱(HPLC)测定释放行为;进行A549细胞摄取与毒性实验;采用H22荷瘤小鼠评价抗肿瘤效果.结果 制备的吉非替尼脂质体呈球形;吉非替尼脂质体缓释效果明显;细胞摄取具有时间、浓度依赖性;吉非替尼脂质体增强了GFB对A549细胞杀伤性(P<0.05);吉非替尼脂质体较生理盐水能抑制荷瘤小鼠肿瘤生长(P<0.05).结论 GFB-PML制备简便,包封率较高,体内外抗肿瘤效果优异.
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