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Mechanism and drug research of AMPK and PPARs in type 2 diabetes mellitus
Author(s): 
Pages: 477-480,489
Year: Issue:  8
Journal: Qilu Pharmaceutical Affairs

Keyword:  2型糖尿病单磷酸腺苷激活的蛋白激酶过氧化物酶增殖物激活受体糖脂代谢分子靶点作用机制研究进展;
Abstract: 2型糖尿病(T2DM)在全球范围内广泛流行,其主要特征为胰岛素抵抗和胰腺β细胞分泌的胰岛素减少,糖脂代谢发生紊乱,其发病原因是多因素的.单磷酸腺苷(adenosine monophosphate,AMP)激活的蛋白激酶(AMP-ac-tivated protein kinase,AMPK)和过氧化物酶增殖物激活受体(peroxisome proliferater-activated receptors,PPARs)作为体内代谢过程的关键调节因子,对糖脂代谢平衡有着巨大贡献.本文着重综述两者在2型糖尿病发生发展中的作用机制,以及相应的药物对2型糖尿病的治疗效果和作用机制,以期为2型糖尿病药物的研发提供参考.
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