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EFFECTS OF SOLUBLE CD40 LIGAND ON ACUTE IRRADIATION INJURY OF MICE
Author(s): 
Pages: 37-41
Year: Issue:  1
Journal: RADIATION PROTECTION

Keyword:  可溶性CD40配体免疫系统辐射;
Abstract: CD40和CD40L的相互作用在机体细胞和体液免疫调节及其应答中起重要作用,注射可溶性CD40L(sCD40L)可促进骨髓移植小鼠粒细胞和血小板数量的恢复.本实验采用外周血细胞计数、白细胞分类计数、免疫荧光标记和流式细胞技术,探讨了sCD40L对小鼠急性辐射损伤的救治作用.结果显示,体内注射sCD40L以最佳剂量100 μg处理受照小鼠时可明显延长其存活时间,并促进CD8+T细胞比例和CD4+/CD8+T细胞比值的恢复.说明sCD40L对受照小鼠免疫系统损伤具有一定的修复作用.
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