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xin xing ji yin bian ji ji shu crispr/cas9 zai xin xue guan xi tong yan jiu zhong de qian zai ying yong ji tiao zhan
Author(s): 
Pages: 225-226
Year: Issue:  33
Journal: Venture Capital

Keyword:  CRISPR/Cas9基因编辑心血管系统;
Abstract: CRISPR/Cas是细菌和古生菌对抗病毒、质粒或其他外源DNA侵染的获得性免疫系统,利用CRISPR RNAs(crRNAs)引导Cas核酸酶沉默入侵的核酸.相较已报道的ZFN和TALEN,该技术更高效及廉价,且可同时编辑多个基因.经过遗传工程改造后的CRISPR/Cas9已经作为一种新型的基因编辑工具应用于多种生物的基因组编辑.本篇综述主要介绍了CRISPR/Cas9作为研究心血管系统的有力工具以及治疗心血管疾病的新型措施的应用前景及面临的挑战.
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