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Simultaneous determination of liquiritigenin and ammonium glycyrrhizinate in Shuqing Oral Liquid by HPLC
Author(s): 
Pages: 148-151
Year: Issue:  3
Journal: Qilu Pharmaceutical Affairs

Keyword:  高效液相色谱疏清口服液甘草素甘草酸铵含量测定;
Abstract: 目的 采用高效液相色谱(HPLC)法建立同时测定疏清口服液中甘草素、甘草酸铵的含量测定方法.方法 色谱条件为Agilent Zorbax SB C18(4.6 mm×150 mm,3.5μm)色谱柱;流动相A为体积分数0.1%磷酸水溶液,B为乙腈,进行梯度洗脱,梯度洗脱程序:0~14 min A相的比例保持84%,14~19 min,A相的比例由84%降至50%,19~50 min A相的比例由50%降至0%;流速为1.0 mL?min-1;检测波长为237 nm;柱温为35℃.结果 甘草素、甘草酸铵的线性范围分别为2.56~102.40、8.22~328.64μg?mL-1;甘草素、甘草酸铵的精密度RSD值分别为:0.20%、0.37%;加样回收率分别为101.1%(RSD值为1.95%)、103.0%(RSD值为0.86%).结论 该方法准确度高、重复性好、专属性强可用于甘草酸铵、甘草素的含量测定.
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