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Research progress of antiinfective drugs acting on bacterial aminoacyl-tRNA synthetase
Author(s): 
Pages: 125-134,139
Year: Issue:  3
Journal: Qilu Pharmaceutical Affairs

Keyword:  耐药性氨酰-tRNA合成酶抑制剂抗感染药物;
Abstract: 细菌耐药问题已对全球公共卫生构成了重大的威胁,研发新的抗菌药物成了紧迫的任务.氨酰-tRNA合成酶作为催化特定氨基酸与tRNA结合的关键酶,在蛋白质合成中发挥了重要作用,由于真核细胞与原核细胞在酶的精细结构上存在差异,为设计针对细菌氨酰-tRNA合成酶的抑制剂提供结构基础.本文对细菌氨酰-tRNA合成酶的结构、作用机制及分类进行概述,并从酶抑制剂的来源出发,对针对此靶点的抗感染药物研究现状进行系统综述.
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