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Isolation and screening of deep-sea bacteria with quorum sensing inhibitory activity
Author(s): 
Pages: 71-74,87
Year: Issue:  2
Journal: FAJIAO KEJI TONGXUN

Keyword:  deep-sea sedimentsdeep-sea bacteriaquorum sensing inhibitory activityChromobacterium violaceumdual strain screening model;
Abstract: In order to obtain novel and effective natural product resources for anti-infection drugs targeting the quorum sensing system of pathogens ,screening of bacterial strains with quorum sensing inhibitory activity was carried out . The bacterial strains were isolated from deep-sea sediments using a 10-fold dilution coating plate method .A double layer agar diffusion method was established using dual strain Chromobacterium violaceum ATCC12472 and Chromobacterium violaceum CV026 as reporter .Fifty deep-sea bacteria were isolated from the samples ,and 3 strains with strong quorum sensing inhibitory activity were obtained .The results showed that many deep-sea bacteria have exhibited the ability of quorum sensing inhibition ,w hich is expected to be an important source of natural quorum sensing inhibitors and natural drug lead compounds .
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