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Research progress on application of functionalized nanoparticles in brain targeted drug delivery
Author(s): 
Pages: 597-599,603
Year: Issue:  10
Journal: Qilu Pharmaceutical Affairs

Keyword:  纳米粒功能化脑靶向脑部治疗;
Abstract: 血脑屏障的存在,导致药物不能有效到达靶部位发挥作用,极大地影响神经系统药物的发展和进步.纳米技术已被证明是用于脑靶向治疗的一种有效工具,尤其在脑肿瘤和神经退行性疾病中应用甚广.功能化纳米粒通过表面修饰等提高药物的顺应性,在药物原来的治疗基础上,达到更加精准的靶向性,高效率在靶部位聚集,起到治疗作用.本文主要综述功能化纳米粒及其功能化策略,总结了影响功能化纳米粒脑靶向运输的因素,同时对功能化的纳米粒在脑部疾病治疗中的优势和应用进行阐述,为其相关研究提供参考.
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