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Research progress of natural flavonoids in prevention and treatment of diabetic nephropathy
Author(s): 
Pages: 593-596
Year: Issue:  10
Journal: Qilu Pharmaceutical Affairs

Keyword:  糖尿病肾病(DN)黄酮氧化应激血糖;
Abstract: 糖尿病肾病(DN)是一种严重的糖尿病并发症,其发病机制复杂而多样.现代药理研究表明,天然黄酮类化合物具有多种潜在药用价值,对糖尿病肾病的防治作用就是其中之一.黄酮类化合物抗糖尿病肾病的作用机制是多方面药理活性的综合结果,包括通过抗氧化应激与清除自由基、抗炎、改善血糖血脂紊乱、抗凋亡、调节血管舒张及改善血流动力学异常等途径来实现.在查阅近年来国内外发表的相关文献后,对黄酮类化合物在糖尿病肾病防治中的多种作用及相关机制进行综述,以期为糖尿病肾病防治药物的研发提供参考.
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