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Study on the determination method of nifedipine in Beagle plasma
Pages: 384-387,429
Year: Issue:  7
Journal: Qilu Pharmaceutical Affairs

Keyword:  硝苯地平高效液相色谱法尼群地平;
Abstract: 目的 建立高效液相色谱法测定比格犬血浆中硝苯地平的含量.方法 高效液相色谱法.色谱柱:C18色谱柱(4.6 mm×250 mm,5μm);进样量20μL;流动相为乙腈:水=55:45;流速1 mL·min-1;柱温30℃;检测波长237 nm.结果 线性方程AS/AI=0.000946X-0.002187(r=0.9992),线性范围(5~500 ng·mL-1),高、中、低3种浓度的硝苯地平测得的日内及日间精密度分别小于5.20%和3.59%,绝对提取回收率均大于71%,血浆中最低检测浓度为5 ng·mL-1.结论 该方法操作简单方便,结果准确、稳定,可用于比格犬血浆中硝苯地平含量的测定和药动学研究.
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