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Preparation and prescription optimization of Captopril Pulse Tablets
Author(s): 
Pages: 516-519
Year: Issue:  9
Journal: Qilu Pharmaceutical Affairs

Keyword:  卡托普利脉冲片星点设计;
Abstract: 目的 以卡托普利为药物模型,用其制备蜡质脉冲片.方法 采用湿法制粒制备速释片芯,再用熔融法制备蜡质包衣,采用干法包衣技术制备卡托普利脉冲片;以释药时滞为指标,采用星点设计进行实验,通过效应面法预测最佳处方,并对其进行验证.结果 优化得到最优处方,交联聚乙烯吡咯烷酮为10%,聚乙二醇6000为34.32%,硬度为4,优化得到的处方时滞在250 min,并且脉冲片能够在25 min左右起漂,并能持续漂浮.结论 采用星点设计-效应面法优化出来的处方结果较为良好,并且得到的脉冲片具有良好的控释能力.
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