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Antibacterial effect of fluconazole resistant Candida by using Compound Fluconazole Gel
Author(s): 
Pages: 638-641
Year: Issue:  11
Journal: Qilu Pharmaceutical Affairs

Keyword:  复方氟康唑凝胶氟康唑黄芩苷假丝酵母菌耐药性抑菌效果;
Abstract: 目的 验证复方氟康唑凝胶对耐氟康唑假丝酵母菌的抗菌效果.方法 选用琼脂扩散法,比较复方氟康唑凝胶与氟康唑凝胶对耐氟康唑假丝酵母菌的体外抑菌效果;通过感染耐氟康唑假丝酵母菌大鼠治疗试验,比较复方氟康唑凝胶与氟康唑凝胶治疗效果.结果 复方氟康唑凝胶抑菌圈直径(18.55±0.03)mm(n=20),氟康唑凝胶抑菌圈直径(7.12±0.01)mm(n=20),差异具有统计学意义(P<0.05);复方氟康唑凝胶治疗感染耐氟康唑假丝酵母菌大鼠15 d的转阴率为80%,氟康唑凝胶为40%,差异具有统计学意义(P<0.05,n=15);复方氟康唑凝胶抑制阴道灌洗液炎性细胞因子水平能力、减轻病变损伤程度明显高于氟康唑凝胶(P<0.05,n=15).结论 复方氟康唑凝胶对耐氟康唑假丝酵母菌的抗菌效果肯定,较氟康唑凝胶具有优势.
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