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Study on the determination of platinum content of cisplatin in rat plasma
Author(s): 
Pages: 315-317,331
Year: Issue:  6
Journal: Qilu Pharmaceutical Affairs

Keyword:  顺铂石墨炉原子吸收;
Abstract: 目的 建立大鼠血浆中铂含量测定的方法学,探讨顺铂经静脉注射给药后在大鼠体内的药动学过程.方法 采用浓硝酸消解法\石墨炉原子吸收光谱(GFAAS)法测定血浆中铂含量.结果 第一步干燥温度100℃,时间20 s,第二步干燥温度150℃,时间30 s;灰化温度1500℃,时间30 s,升温速率150℃·s-1;原子化温度为2700℃,净化温度2800℃下,此法测定铂标准曲线方程为:A=0.00249C+0.0072,相关系数为R2=0.9997;检出限为1.93 ng·mL-1.结论 石墨炉原子吸收光谱法测定血浆中铂含量的方法准确可靠,简便易行.
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