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Effect of Tongluo Xingnao Effervescent Tablets on the expression of the nuclear clock gene in the suprachiasmatic nucleus of VD model rats
Author(s): 
Pages: 311-314
Year: Issue:  6
Journal: Qilu Pharmaceutical Affairs

Keyword:  通络醒脑泡腾片血管性痴呆认知能力生物钟基因;
Abstract: 目的 考察通络醒脑泡腾片对血管性痴呆(VD)模型大鼠视交叉上核生物钟基因表达的影响.方法 采用双侧结扎颈总动脉法(2-VO法)制备血管性痴呆大鼠模型,采用Morris水迷宫评价其认知功能;反转录聚合酶链式反应(RT-PCR)法检测各组大鼠视交叉上核生物钟基因Clock、Bmal、Per2基因的表达.结果 通络醒脑泡腾片能够改善血管性痴呆模型大鼠学习记忆功能,可上调模型大鼠视交叉上核Bmal、Clock和Per2基因表达(P>0.05).结论 通络醒脑泡腾片调节血管性痴呆模型大鼠认知能力与其调节视交叉上核生物钟基因Bmal、Clock和Per1有关.
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