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The effects of Jing′an Oral Liquid on DOI induced tourette syndrome in rats
Author(s): 
Pages: 322-324,355
Year: Issue:  6
Journal: Qilu Pharmaceutical Affairs

Keyword:  静安口服液多发性抽动症行为学大鼠;
Abstract: 目的 本文拟探讨静安口服液对1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane(DOI)致模型大鼠行为学的改善作用.方法 采用腹腔注射DOI制备抽动症大鼠模型,48只模型大鼠分为:模型组,硫必利(15 mg·kg-1)组,静安口服(3.5、7 g·kg-1)两个剂量组.硫必利组与静安口服液组给予相应的药物,动物每天给药1次,连续21 d,空白组与模型组给予相应体积的生理盐水,末次给药24 h后做相关行为学检测(刻板实验、糖水偏好、悬尾实验、强迫游泳实验等).结果 静安口服能显著减少1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane致抽动症大鼠刻板行为评分、增加抽动症大鼠糖水偏好、减少悬尾不动时间、强迫游泳不动时间.结论 静安口服液能显著改善1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane诱导的大鼠抽动症行为.
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