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Research progress on biological function of BRPF proteins and its inhibitors
Pages: 356-360
Year: Issue:  6
Journal: Qilu Pharmaceutical Affairs

Keyword:  BRPF表观遗传生物学功能抑制剂Bromodomain;
Abstract: BRPF(bromodomain and PHD finger containing)蛋白作为表观遗传"reader"结构域,能特异性地识别组蛋白"尾部"乙酰化的赖氨酸残基以促进靶基因的转录.本文综述了BPRF蛋白如何识别和结合乙酰赖氨酸标记,讨论了乙酰化组蛋白识别对其生物学功能的重要性,以及总结了BRPF bromodomain抑制剂的研究进展.
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