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Study on in vitro antifungal activity of caltrop steroid saponion against artificial induced drug-resistant Trichophyton rubrum
Author(s): 
Pages: 142-145
Year: Issue:  3
Journal: Qilu Pharmaceutical Affairs

Keyword:  TTS-12人工诱导耐药红色毛癣菌;
Abstract: 目的 研究蒺藜的甾体皂苷成分TTS-12对于耐药皮肤癣菌的抗真菌作用.方法 用含体外浓度递增法对真菌进行培养,分别诱导红色毛癣菌对氟康唑和酮康唑的耐药性,用微量液基稀释法评价菌株的耐药性、稳定性及对TTS-12的敏感度.结果 经过诱导后,耐氟康唑菌株对氟康唑的最小抑菌浓度(MIC)>128μg·mL-1,耐酮康唑菌株对酮康唑的最小抑菌浓度>64μg·mL-1,且传代三次后耐药性相对稳定,TTS-12对氟康唑耐药菌株的最小抑菌浓度范围在4~16μg·mL-1,对酮康唑耐药菌株的最小抑菌浓度范围在4~8μg·mL-1.结论 经过浓度递增方式的培养能够成功诱导红色毛癣菌耐氟康唑和酮康唑的菌株,并且TTS-12对两种耐药菌株有良好的生长抑制作用.
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