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In vitro dissolution curves of Enalapril Maleate Tablets
Author(s): 
Pages: 96-98,114
Year: Issue:  2
Journal: Qilu Pharmaceutical Affairs

Keyword:  马来酸依那普利片溶出曲线生物等效;
Abstract: 目的 通过溶出曲线的检测,探索马来酸依那普利片的溶出行为,降低生物等效性试验的风险.方法检测马来酸依那普利片不同处方的溶出曲线,确定溶出曲线与参比制剂最相似的处方.结果自制片的3个处方中,外加预胶化淀粉为8.64 mg的处方比参比制剂溶出慢,外加预胶化淀粉为28.64 mg的处方比参比制剂快,外加预胶化淀粉为18.64 mg的处方与参比制剂拟合较好.结论通过对马来酸依那普利片不同处方的溶出曲线检测,并与参比制剂进行对比,筛选出能与参比制剂拟合较好的处方,有效的马来酸依那普利片降低了生物等效性试验的风险.
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