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Research progress of origin and developmental differentiation of hepatic macrophage
Author(s): 
Pages: 50-52,59
Year: Issue:  1
Journal: Qilu Pharmaceutical Affairs

Keyword:  巨噬细胞起源分化肝脏;
Abstract: 巨噬细胞存在于所有组织且功能具有多样性.巨噬细胞是肝脏中重要组成部分,对维持组织稳定性及对肝损伤做出快速反应具有不可或缺的作用.研究表明组织中成熟的巨噬细胞起源于胚胎.巨噬细胞包含不同亚群.库普弗细胞为原本就定居在肝脏中具自我维持功能的细胞,区别于单核细胞源性巨噬细胞.不同环境信号进一步决定了肝脏巨噬细胞的分化方向和功能.本文重点讨论肝脏巨噬细胞的起源、分类和分化,并简要介绍其功能.
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