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The relationship between the expression of protooncegene C- erbB- 2, PCNA and gastric carcinoma biologic behavior
Author(s): 
Pages: 726-727
Year: Issue:  10
Journal: ZHEJIANG CLINICAL MEDICAL JOURNAL

Keyword:  胃癌 C-erbB-2 PCNA;
Abstract: 目的探讨胃癌C-erbB-2、PCNA表达及其与病理分化程度、浸润、转移的生物学行为间的关系.方法采用S-P法,对胃癌组织切片中C-erbB-2和PCNA进行免疫组化标记及原位观察,统计其与胃癌临床病理生物学行为间的相关性.结果48例中C-erbB-2阳性表达65%,阳性程度与肿瘤组织的不同分化程度之间显著相关,PCNA阳性表达77%,阳性程度与淋巴结有否转移之间有显著相关.C-erbB-2与PCNA之间无密切关系.结论C-erbB-2和PCNA检测可作为判断胃癌生物学行为和指导治疗的良好指标,但代表的临床意义不同.
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