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Effect of Paroxetine Hydrochloride and Pinaverium Bromide Therapy in Patients with Irritable Bowel Syndrome
Author(s): 
Pages: 9-11
Year: Issue:  9
Journal: HAINAN MEDICAL JOURNAL

Keyword:  肠易激综合征盐酸帕罗西汀匹维溴胺治疗;
Abstract: 目的比较小剂量抗抑郁药物盐酸帕罗西汀和匹维溴胺与单独应用匹维溴胺治疗肠易激综合征的疗效.方法将70例符合罗马Ⅰ诊断标准的肠易激综合征患者随机分为两组:治疗组(简称P+P组),34例应用盐酸帕罗西汀(每日一次,每次口服10 mg)加匹维溴胺(每日三次,每次口服50mg);对照组(简称P组),应用匹维溴胺,疗程均为12 周.结果在胃肠道症状方面,P+P组对腹痛程度和腹痛天数、腹胀程度和腹胀天数及大便次数的改善优于P组,而在大便性状改善方面两组间则无差异;在精神和躯体症状方面, P+P组对焦虑及腰背痛症状的改善优于P组,其它如抑郁、不愉快、疲惫及头痛改善方面两组间也无差异.结论小剂量盐酸帕罗西汀加匹维溴胺能明显改善肠易激综合征患者的胃肠道及部分精神和躯体症状,是肠易激综合征药物治疗的一种有效方法.
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