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Study on induction of cytochrome P450 enzymes by schisandrin B in vitro
Author(s): 
Pages: 559-564,574
Year: Issue:  10
Journal: Qilu Pharmaceutical Affairs

Keyword:  五味子乙素诱导细胞色素P450;
Abstract: 目的 研究五味子乙素对细胞色素P450(CYP450)酶活性和mRNA表达是否有诱导作用.方法 采用底物法测定人肝原代细胞CYP1A2、CYP2B6和CYP3A4酶的活性,荧光定量PCR检测mRNA的表达.结果 五味子乙素对CYP1A2和CYP3A4的酶活性均低于阳性对照的40%,高浓度的五味子乙素对CYP2B6的酶活性均高于阳性对照的40%;五味子乙素对CYP1A2的mRNA表达小于阴性对照的4倍,高浓度的五味子乙素对CYP2B6和CYP3A4的mRNA表达大于阴性对照的4倍.结论 五味子乙素对CYP1A2和CYP3A4的酶活性没有诱导作用,对CYP2B6的酶活性有潜在诱导作用;五味子乙素对CYP1A2的mRNA表达没有诱导作用,对CYP2B6和CYP3A4的mRNA表达有潜在诱导作用.
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