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Research progress on the role of CYP27A1 in tumor progression
Pages: 170-173
Year: Issue:  3
Journal: Qilu Pharmaceutical Affairs

Keyword:  Vitamin D3Breast CarcinomaProstate CancerColorectal Cancer;
Abstract: CYP27A1 is a member of the cytochrome P450,and is commonly known as sterol 27-hydroxylase.This enzyme is located in many different tissues where it is found within the mitochondria.It is most prominently involved in the biosynthesis of bile acidsin both the classic and acidic pathways,thus maintaining the balance of bile acids.The other well-known function is activating vitamin D3 catalytically.CYP27A1 is closely related to the formation of a variety of tumors,such as breast cancer,prostate cancer,colorectal cancer and liver cancer,etc.This article summarized the main role of CYP27A1 in the first three tumors so as to lay the foundation for the research of mechanism of tumorigenesis.
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