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Comparative Study on Iron Deficiency Anemia Rats Model by Three Different Formula Feeds
Pages: 433-436
Year: Issue:  6
Journal: Laboratory Animal and Comparative Medicine

Keyword:  Iron deficiency anemiaWistar ratsHemoglobin(Hb);
Abstract: 目的 探讨三种不同饲料配方对建立Wistar大鼠缺铁性贫血模型的影响.方法 将3~4周龄Wistar大鼠分为4组,即A、B、C和正常对照组,A、B、C组分别饲喂3种不同配方饲料,正常对照组饲喂正常饲料.实验持续35 d,实验期间每周称量各组大鼠体质量及摄食量同时观察大鼠行为、外观体征等变化.35 d后取血,检测相关血常规指标包括血红蛋白(Hb)含量、红细胞压积等.结果 A组大鼠Hb含量降到90 g/L以下,且行为和体态表现也符合缺铁贫血特征,达到造模要求;B组大鼠Hb含量没有降低;C组大鼠Hb含量有所降低但未达到90g/L以下.结论 A组饲料配方可以成功建立大鼠缺铁性贫血模型,B、C组配方均不适用于缺铁性模型的建立.
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