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Simultaneous determination of morphine and codeine in Qiangli Pipa Syrup by HPLC
Pages: 466-468
Year: Issue:  8
Journal: Qilu Pharmaceutical Affairs

Keyword:  强力枇杷露吗啡与可待因高效液相色谱法;
Abstract: 目的 提高强力枇杷露的质量标准.采用高效液相色谱法对强力枇杷露中的吗啡与可待因进行含量的同时测定.方法 色谱柱为Agilent Eclipse C18色谱柱(4.6 mm×250 mm,5μm),以乙腈-0.01 mol·L-1磷酸二氢钾-磷酸-三乙胺溶液(5∶95∶0.2∶0.4)为流动相,流速1.0 mL·min-1,检测波长220 nm.结果 吗啡的进样量在0.229 3~4.586 μg范围内呈良好的线性关系(r=0.999 2),平均加样回收率为100.35%,RSD为2.87%(n=6);可待因的进样量在0.037 11~0.741 1μg范围内呈良好的线性关系(r=0.999 9),平均加样回收率为106.78%,RSD为2.09%(n=6).结论 方法经济合理、简便准确,可用于强力枇杷露中吗啡和可待因的含量测定.
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