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Effects of Mudan Particles combined with irbesartan on the levels of serum transforming growth factor-β1 and homocysteine in patients with early diabetic nephropathy:A randomized,open,parallel,controlled study
Author(s): 
Pages: 545-547,558
Year: Issue:  9
Journal: Qilu Pharmaceutical Affairs

Keyword:  Mudan ParticlesDiabetic nephropathyTransforming growth factor-β1Homocysteine;
Abstract: Objective To investigate the effects of Mudan Particles combined with irbesartan on the levels of serum transforming growth factor-β1(TGF-β1)and homocysteine(Hcy)in patients with early diabetic nephropathy.Methods Application of prospectively randomized,open,parallel,controlled methods,a total of 72 patients with early diabetic ne-phropathy were selected,and were randomly divided into two groups for Mudan Particles combined with irbesartan (combined therapy)or irbesartan treatment,respectively.Changes in urinary albumin excretion rate(UAER),urine β2-mi-croglobulin(β2-MG),the levels of serum TGF-β1 and Hcy were measured and compared between two groups at both pre-and post-treatment of 48 weeks.Results There were no statistically significant difference in the baseline clinical character-istics of study participants between two treatment groups( P﹥0. 05 ). Comparison of therapy-related differences between groups showed that the combined therapy was better in reducing UAER,urineβ2-MG and serum TGF-β1 than the irbesar-tan group[(-37±12 vs -22±10)μg·min-1,(-0.40±0.17 vs -0.24±0.12)mg·L-1,(-31±15 vs -14±12)U·L-1,re-spectively,all P﹤0.01].Conclusion Compared with irbesartan monotherapy,Mudan Particles combined with irbesartan treatment can better reduce serum TGF-β1 levels,decrease UAER and urine β2-MG,and may exert kidney protection effects in patients with early diabetic nephropathy.
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