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The forming process and acute toxicity test of Jianpi Qushi Granules
Author(s): 
Pages: 535-537,544
Year: Issue:  9
Journal: Qilu Pharmaceutical Affairs

Keyword:  Jianpi Qushi GranulesResponse surface methodologyAcute toxicityForming process;
Abstract: Objective To research the forming process of Jianpi Qushi Granules and its acute toxicity after administra-tion.Methods Adjuvants were definited in forming process,the amount of dextrin and the concentration of ethanol were definited by response surface methodology.After preparation of the samples,the acute toxicity test of Jianpi Qushi Granules in mice were carried out,and definited the acute toxicity according to the death of mice.Results The preparation of Jianpi Qushi Granules was yellow,uniform size,the amounts of excipients were 17% dextrin,90% ethanol.The acute toxicity results was that:the largest dosage was 120 g·kg-1 for single dose in mice.Conclusion The preparation process of Jianpi Qushi Granules with 17% dextrin,90% ethanol was reliable,safe and low toxicity,and suitable for clinical application.
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