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Study on anti -tumor activity of combined application of cisplatin and DMPIBPA in vitro
Pages: 133-135
Year: Issue:  3
Journal: Qilu Pharmaceutical Affairs

Keyword:  Resveratrol derivativesDDPCombined applicationAnti -tumor activityMTT assay;
Abstract: Objective To synthesize Z -2 -(3,5 -dimethoxyphenyl -3 -)4 -isobutoxyphenyl)acrylonitrile (DMPIBPA)and preliminarily study the anti -tumor activities of combined application of DMPIBPA with cisplatin(DDP). Methods DMPIBPA was synthesized with 3,5 -dimethoxybenzoic acid as a starting material and HCT116 and L -02 cells were treated with DDP,DMPIBPA and DDP +DMPIBPA,respectively,and the proliferation inhibitory effects were de-termined by MTT assays.Results In HCT116 cells,inhibition ratio of DMPIBPA(100 μmol·L -1 )was 35.3% ±5.0%, and the inhibition ratio of DDP (250 μmol · L -1 ) was 28.9% ±1.3%.When combined use of DMPIBPA (100μmol·L -1 )with DDP(250 μmol·L -1 ),the inhibition ratio was 65.4% ±2.0% in HCT116 cells but was only 36.2%±0.5% in L -02 cells.The growth inhibition activity of combined application of DMPIBPA and DDP significantly stronger than either one compound in HCT116 cells.Conclusion When combined use of DDP and DMPIBPA,it expressed selective and synergistic inhibition effect on HCT116 cells but had not any effect on L -02 cells.
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