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Preparation of curcumin -tetrandrine co -delivery antiviral compound recipe liposome
Pages: 157-160
Year: Issue:  3
Journal: Qilu Pharmaceutical Affairs

Keyword:  CurcuminTetrandrineAntiviralLiposomeasCo -delivery;
Abstract: Objective To prepare hyaluronan oligosaccharides(oHA)modified antiviral liposome containing curcumin and tetrandrine,and study its release in vitro and stability.Methods The co -deliver antiviral liposomes was prepared by film dispersion method with particle size and entrapment rate as two important indicators,using particle size analyzer to de-termine the particle size and ultraviolet spectrophotometric method for the determination of entrapment efficiency.Results With Box - Behnken response surface optimization method,the optimal preparation (cholesterol and phospholipid ratio) was 2.5∶1.The best curcumin -tetrandrine proportion was 2.8∶1,and oHA was 1.80%.The particle size was 201.06 nm and entrapment efficiency was 70.94%.Conclusion The preparation method showed that liposomes had good stability,u-niform particle size distribution.It proved that the liposome had good in vitro release activity,good stability and had the po-tential use for antiviral nanocarriers.
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