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The therapeutic effect of clopidogrel on different weight patients with acute ischemic stroke
Author(s): 
Pages: 175-178
Year: Issue:  3
Journal: Qilu Pharmaceutical Affairs

Keyword:  Acute ischemic strokeClopidogrelWeightPlatelet aggregation rate;
Abstract: Objective Based on normal body mass index,to study the therapeutic effect of clopidogrel on different weight patients with acute ischemic stroke.Methods A total of 126 normal -weight patients with acute ischemic stroke in department of neurology,Nanjing First Hospital from September 2012 to May 2013 were enrolled and evenly divided by gen-der and median weight into low and high weight groups.Platelet aggregation was detected before and 7 days later after taking standard clopidogrel antiplatelet therapy,and stroke recurrence rate and adverse event occurrence rate was followed -up for one year.Results No significant difference in platelet aggregation before (low weight group was 74.1% ±13.2% and high weight group was 74.7% ±13.6%,P =0.802)while statistical difference 34.4% ±9.8% and 39.1% ±14.4% respec-tively,P =0.034)was found 7 days later after taking standard clopidogrel antiplatelet therapy.Two groups of stroke recur-rence rate and adverse event occurrence rate showed no significant difference in one year′s following up.Conclusion Within the range of normal BMI,patients with a lower body weight would have a better anti -platelet effect after taking clo-pidogrel.But further research was needed to see whether such effect would reduce stroke recurrence or increase adverse e-vents.
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