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Correlation between glomerular filtration rate and coronary artery disease
Author(s): 
Pages: 3304-3306,3307
Year: Issue:  22
Journal: Hainan Medical Journal

Keyword:  Glomerular filtration rateCoronary artery diseaseCoronary artery stenosis;
Abstract: Objective To explore the correlation between glomerular filtration rate (eGFR) and coronary ar-tery disease (CAD), as well as between eGFR and coronary artery stenosis. Methods A total of 349 hospitalized patients undergoing coronary angiography were enrolled into this research, which were divided into three groups according to eG-FR level:high eGFR group (eGFR≥90 ml/min·1.73 m, 125 cases), moderate eGFR group (60 ml/min·1.73 m≤eGFR<90 ml/min·1.73 m, 118 cases), and low eGFR group (eGFR<60 ml/min·1.73 m, 106 cases). CAD was defined as over 50%reduction of lumen diameter at least in one major coronary artery. The severity of coronary artery stenosis was de-fined by the Gensini score. The baseline clinical characteristics and coronary angiogram were compared among vari-ous groups. Bivariate correlation and multivariate logistic regression analysis were performed to analyze the correla-tion between eGFR and CAD, as well as between eGFR and coronary artery stenosis. Results Incidence of CAD, and Gensini score of coronary artery in moderate and low eGFR group were significantly higher than that in high eG-FR group (P<0.05). Bivariate correlation analysis showed that eGFR was negatively correlated with CAD and Gensini score of coronary artery stenosis (r=-0.380 and r=-0.315, respectively, all P<0.05). Multivariate logistic regression analysis showed that eGFR was independent risk factor for CAD and coronary artery stenosis (OR=1.450, 95%CI:1.026~2.241 and OR=1.374, 95%CI:1.047~2.164, respectively, all P<0.05). Conclusion eGFR is closely correlated with CAD and coronary artery stenosis. It serves as an independent risk factor for CAD and coronary artery stenosis.
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