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TheraPeutic ation of Paclitaxel liPosome mediated by Penetrating PePtides on tumor
Pages: 137-140
Year: Issue:  3
Journal: Qilu Pharmaceutical Affairs

Keyword:  Penetrating peptidesLiposomesPaclitaxelCellular uptakeAntitumor activities;
Abstract: Objective To prepare and exosyndrome F3 modified paclitaxel liposome and evaluate the cellular uptake and antitumor activities. Methods The liposomes were prepared by film — dispersed method;The studies of cellular uptake and antitumor activities were performed in A549 cells and H22 — bearing mice,respectively. Results The F3 modified lipo-somes with a diameter size of around 90 nm were uptaken by cells and thus had better antitumor activities. Conclusion F3 penetrating peptides could enhance the cellular uptake and thus improve the therapeutic outcome of drugs.
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