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Effect of ophiopogonis-extract on the level of uric protein and the expression of adiponectin in mice with insulin resistance
Author(s): 
Pages: 321-322,331
Year: Issue:  6
Journal: Qilu Pharmaceutical Affairs

Keyword:  Ophiopogonis-extractPregnancyInsulin resistanceUric proteinAdiponectin;
Abstract: Objective To investigate the effect of ophiopogonis-extract on the level of Uric Protein and the expression of adiponectin in mice with insulin resistance. Methods The IR model was established by pregnancy mice in 1 week. Total of 40 model mice were randomly divided into ophiopogonis-extract 125 mg·kg-1 group,ophiopogonis-extract 500 mg·kg-1 group,model group. And 10 normal pregnancy mice were served as control group. Mice in control group and model control group were daily gavaged with NS for 14 d,and mice in ophiopogonis-extract 125 mg·kg-1 group and ophiopogonis-ex-tract 125 mg·kg-1 group were gavaged with ophiopogonis-extract 125 mg·kg-1 and 500 mg·kg-1 respectively for 14 d. The fasting blood glucose,serum insulin and uric protein were detected,the insulin resistance( IR)was calculated,the ser-um adiponectin was determined by ELISA. Results The fasting blood glucose,serum insulin and uric protein were decrease in groups treated with ophiopogonis-extract compared with model group,but the level of APN expression in ophiopogonis-extract groups was higher than in model group. Conclusion Ophiopogonis-extract had definite protective effect,and could help to prevent PIH in pregnancy mice with insulin resistance.
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