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Effect of sodium ozagrel on the expression of platelet membrane glycoprotein and the clinical efficacy with acute cerebral infarction patients
Author(s): 
Pages: 230-232
Year: Issue:  4
Journal: Qilu Pharmaceutical Affairs

Keyword:  脑梗死血小板活化血小板膜GPⅡb/Ⅲa复合物p-选择素抗血小板药物奥扎格雷钠;
Abstract: 目的 研究奥扎格雷钠对患者血小板膜GPⅡb/Ⅲa复合物和p-选择素、NIHSS评分的影响,探讨奥扎格雷钠对血小板活化的影响及与临床疗效的关系.方法 对脑梗死急性期患者入院第1天和第14天进行NIHSS评分,并应用流式细胞术检测血小板膜GPⅡb/Ⅲa复合物和p-选择素.将患者分为阿司匹林组、奥扎格雷钠组,对比两组患者NIHSS评分和血小板膜GPⅡb/Ⅲa复合物和p-选择素的差异.结果 两组治疗第14天奥扎格雷钠组的血小板膜NIHSS、GPⅡb/Ⅲa复合物和p-选择素均比阿司匹林组下降更明显(P<0.05).结论 阿司匹林和奥扎格雷钠均可降低血小板活化程度,从而缓解脑梗死病情,而奥扎格雷钠作用更强,取得的临床疗效更为明显.
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