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Comparison of long term effects of lisinopril,amlodipine besylate and ibesartan on cardio - pulmonary function in hypertensive patients
Author(s): 
Pages: 299-300,308
Year: Issue:  5
Journal: Qilu Pharmaceutical Affairs

Keyword:  LisinoprilCardiopulmonary exercise testHypertensionVO2max;
Abstract: Objective To compare the effects of long - term use of angiotensin converting enzyme inhibitor lisinopril, calcium antagonist amlodipine besylate and angiotensin Ⅱ receptor antagonist irbesartan on cardio - pulmonary function in Hypertensive patients. Methods 96 patients with hypertension were randomly divided into three groups,treated with lisino-pril tablets 10 mg·d - 1 ,amlodipine besylate tablets 5 mg·d - 1 and irbesartan tablets 150 mg·d - 1 ,respectively. After 6 and 12 months,compared three groups of patients with blood pressure and VO2max . Results After 6 and 12 months,the de-creases in blood pressure levels of lisinopril group were:(33. 09 ± 15. 50)/(14. 18 ± 9. 44)mmHg,(36. 49 ± 17. 10)/(15. 28 ± 8. 24)mmHg,amlodipine besylate group were:(31. 80 ± 12. 93)/(12. 72 ± 9. 76)mmHg,(33. 85 ± 15. 82)/(17. 28 ± 7. 56)mmHg and irbesartan group were(32. 90 ± 14. 82)/(15. 21 ± 10. 85)mmHg,(33. 85 ± 13. 72)/(17. 42 ± 11. 54)mmHg. There were no significant difference. 6 and 12 months later,VO2max of patients respectively,lisinopril group:20. 22 ± 1. 15,20. 99 ± 1. 37;amlodipine besylate group:17. 87 ± 1. 43,18. 00 ± 1. 13;irbesartan group:17. 98 ± 1. 33, 18. 26 ± 1. 53. Compared with the other groups,VO2max of patients in lisinopril group were improved. Conclusion Long term use of lisinopril can control blood pressure and improve cardio - pulmonary function of hypertensive patients.
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