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Study on immunity modulation and clinical efficacy in treating 68 vitiligo patients with polysaccharide nucleic acid fraction of Bacillus Calmette Guerin
Author(s): 
Pages: 182-183,186
Year: Issue:  3
Journal: Qilu Pharmaceutical Affairs

Keyword:  卡介菌多糖核酸白癜风临床疗效免疫调节;
Abstract: 目的 观察卡介菌多糖核酸治疗白癜风的临床疗效.方法 将68例白癜风患者随机分为两组,治疗组36例肌注卡介菌多糖核酸注射液联合外用30%补骨脂酊,对照组32例单纯外用30%补骨脂酊,给药3个月.分别用流式细胞术和ELISA方法检测卡介苗多糖核酸治疗白癜风前后患者外周血T细胞亚群、IL-10和IFN-γ的水平.结果 治疗组总有效率为91.7%,对照组总有效率59.4%,治疗组显著优于对照组(P<0.01).卡介菌多糖核酸治疗后,患者CD4+百分比及CD4+/CD8+比值较治疗前升高,CD8+百分比降低,IFN-γ水平升高(P<0.05),IL-10水平下降(P<0.05).结论 卡介菌多糖核酸可显著改善患者细胞免疫功能,能有效治疗白癜风.
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