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Study on the compatible stability of six kinds of β-lactam antibiotics injection in two transfusion solutions
Author(s): 
Pages: 24-26
Year: Issue:  1
Journal: Qilu Pharmaceutical Affairs

Keyword:  果糖注射液葡萄糖注射液高效液相色谱法pH值;
Abstract: 目的 研究6种β-内酰胺类抗生素分别同5%葡萄糖注射液和果糖注射液配伍后溶液的稳定性.方法 以注射剂临床常用量为配伍参考,室温下分别在与溶媒配伍0、2、6 h后进行主要成分含量、pH值、不溶性微粒及外观等研究.结果 阿莫西林钠舒巴坦钠、阿莫西林钠克拉维酸钾、头孢哌酮钠舒巴坦钠与两种溶媒配伍后在主要成分含量方面差异明显;哌拉西林钠他唑巴坦钠、头孢哌酮钠舒巴坦钠与两种溶媒配伍后pH值有明显不同.结论 6种β-内酰胺类抗生素在偏酸性溶媒中不稳定.
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