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Improvement of the assay method of glimepiride
Author(s): 
Pages: 507-508
Year: Issue:  9
Journal: Qilu Pharmaceutical Affairs

Keyword:  格列美脲含量测定滴定高效液相色谱法;
Abstract: 目的 改进格列美脲原料含量测定的方法.方法 采用高效液相色谱法,Agilent Zorbax SB-C18色谱柱(4.6 mm×250 mm,5 μm),以磷酸二氢钠溶液(取0.5 g磷酸二氢钠,加水500 mL溶解,用磷酸调pH至2.5)-乙腈(500∶ 500)为流动相,流速1.0 mL·min-1,检测波长为228 nm.结果 系统适用性符合要求,格列美脲的定量限为0.1 ng,在87.92~1 318.80 ng范围内线性关系良好(r=1.000 0).平均回收率为100.3%,RSD为0.8%(n=9).结论 建立的方法准确、灵敏,可代替滴定法用于格列美脲的含量测定.
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