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Pharmacokinetic study of dADT and acetylizad dADT,metabolites of tribendimidine in human
Author(s): 
Pages: 543-545
Year: Issue:  9
Journal: Qilu Pharmaceutical Affairs

Keyword:  三苯双脒高效液相色谱串联质谱法药代动力学代谢;
Abstract: 目的 评价三苯双脒代谢物氨脒和乙酰氨脒人体药代动力学研究.方法 8名健康志愿者单次口服400 mg三苯双脒肠溶片后,采用LC-MS法测定不同时间点三苯双脒代谢物氨脒和乙酰氨脒浓度,DAS 2.0程序计算药代动力学参数.结果 氨脒和乙酰氨脒的药代动力学参数分别为:半衰期t1/2 (5.38±2.15)h和(7.09±2.06)h,达峰时Tmax (5.25±1.25)h和(7.13±2.42)h,峰浓度Cmax (449.38 ±136.41)ng·mL-1和(148.30±117.13)ng·mL-1,血浓度-时间曲线下面积AUC0~36 (4 655.04± 1 113.24)ng·mL-1·h和(1 904.93 ± 976.81)ng·mL-1·h,AUC0~∞分别为(4 768.90±1 158.38)ng·mL-1·h和(1 989.49± 1 014.42)ng·mL-1·h.结论 健康志愿者单次口服400 mg三苯双脒肠溶片后,氨脒和乙酰氨脒体内药代动力学过程均符合w=1/cc的一室模型,吸收、分布迅速.
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