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Comparative studies of frowth and reproductive ability in neuron and microglia transgene mice
Author(s): 
Pages: 25-28,32
Year: Issue:  3
Journal: Laboratory Science

Keyword:  转基因小鼠生长繁殖性能血液生化指标荧光蛋白;
Abstract: 目的:对两种转基因小鼠的生长繁殖方法进行研究.方法:在SPF环境下,用C57BI/6小鼠做对照,采取近亲交配的繁殖方法研究其生长繁殖性能,并检测两种转基因小鼠体内荧光蛋白的表达.结果:两种转基因小鼠的生长繁殖性能均与C57BL/6小鼠相一致,所有脏器重量和绝大多数正常血液生化指标与C57BL/6小鼠无显著性差异(P>0.05);两种转基因小鼠脑片检测可见在不同的年龄段均有相应荧光蛋白的表达.结论:在SPF环境下采用近亲交配繁殖法培育转基因小鼠是成功的.
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