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Synthesis of natural curcumins
Author(s): 
Pages: 125-127
Year: Issue:  3
Journal: JOURNAL OF PHARMACEUTICAL RESEARCH

Keyword:  天然姜黄素类化合物姜黄素一脱甲氧基姜黄素二脱甲氧基姜黄素合成;
Abstract: 目的 以化学合成法制备天然姜黄素类化合物.方法 以对羟基苯甲醛或香草醛和乙酰丙酮为原料经硼络合保护,分别合成姜黄素、一脱甲氧基姜黄素和二脱甲氧基姜黄素,测定熔点,并以氢谱进行结构解析.结果 姜黄素、一脱甲氧基姜黄素和二脱甲氧基姜黄素合成品分别为亮黄色、橙黄色和橙红色粉末,氢谱所确证的结构与已知结构一致.结论 本合成法操作简单,条件温和,可在短时间内制备大量天然姜黄素类化合物,效率较传统的提取分离法大大提高.
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