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Determination of related substances in Ibuprofen Sustained-release Capsules by HPLC
Author(s): 
Pages: 85-87
Year: Issue:  2
Journal: JOURNAL OF PHARMACEUTICAL RESEARCH

Keyword:  布洛芬缓释胶囊有关物质高效液相色谱法;
Abstract: 目的 建立布洛芬缓释胶囊有关物质的高效液相色谱测定方法.方法 Eclipce XDB C18柱,0.076%磷酸溶液-乙腈(66:34)为流动相,流速为1.5 mL·min-1,柱温40 ℃,检测波长为214 nm.结果 布洛芬在0~80.192 μg·mL-1范围内浓度与峰面积线性关系良好,相关系数r=0.999 9(n=9).结论 该方法简单,快速,准确,分离效果好,能作为布洛芬缓释胶囊有关物质的测定方法.
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